4-methoxydalbergione

4-methoxydalbergione is a natural product classified as a benzoquinone, most notably isolated from Dalbergia sissoo and related species[1][6]. It has demonstrated **antitumor activity** in preclinical studies, particularly as a **potent inhibitor of human astroglioma and osteosarcoma cells**, where it induces apoptosis, arrests the cell cycle at the G2/M phase, and alters pathways including p53, TNF, and MAPK signaling[6]. Its primary use is as a research compound, and it is not an approved pharmaceutical. Mechanistically, 4-methoxydalbergione acts by modulating **cell proliferation, cell division, and apoptosis-related signaling pathways**[6]. Studies show that 4-methoxydalbergione rapidly crosses the blood-brain barrier, making it of interest in central nervous system tumor models[6].

Other names

4-methoxydalbergione2-methoxy-5-(1-phenylallyl)-4-benzoquinone2-methoxy-5-(1-phenylallyl)-p-benzoquinone2-methoxy-5-(1-phenylprop-2-enyl)cyclohexa-2,5-diene-1,4-dione(S)-4-methoxydalbergione(-)-4-methoxydalbergione