4-oxoretinol

**Description:**\n4-Oxoretinol (all-trans) is a naturally occurring retinoid metabolite of all-trans-retinol (vitamin A), in which the hydrogens at position 4 are replaced by an oxo group. It acts as a biologically active signaling molecule and has been shown to function as an antineoplastic agent. Mechanistically, it binds to and activates transcription of the retinoic acid receptors (RARs), but not the retinoid X receptors (RXRs). This activation leads to regulation of gene expression involved in cell differentiation and growth arrest, particularly demonstrated in human promyelocytic leukemia cells and F9 embryonic teratocarcinoma cells. Unlike all-trans-retinoic acid, it does not require conversion to an acid moiety for activity and can induce cellular differentiation directly. It also synergizes with interferon-gamma in promoting cell growth arrest[2][3][5][10].

Other names

all-trans-4-oxoretinolall-trans4-oxoretinolall-trans 4-oxoretinol4-ketoretinol62702-55-015-hydroxyretin-4-one