4-P-PDOT

4-P-PDOT (4-phenyl-2-propionamidotetralin) is a potent and selective small molecule antagonist of the melatonin MT2 receptor (MTNR1B). It is widely utilized as a pharmacological tool in preclinical research to differentiate between the physiological roles of the MT1 and MT2 receptor subtypes. By selectively blocking MT2-mediated signaling, 4-P-PDOT has been shown to modulate various biological processes, including inflammatory and neuropathic pain, circadian rhythm regulation, neuroprotection in Parkinson's disease models, and mesenchymal stem cell differentiation. It typically exhibits significantly higher affinity for the MT2 subtype compared to the MT1 subtype, making it a standard reagent for investigating melatonin receptor-specific mechanisms in models of post-traumatic stress disorder (PTSD), osteoarthritis, and osteoporosis.

Other names

4-phenyl-2-propionamidotetralin4-phenyl-2-propionamido-tetralin