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5(S),6(R)-lipoxin A4 methyl ester
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Inhalation, Intraperitoneal, Subcutaneous, Topical
01
Overview
5(S),6(R)-lipoxin A4 methyl ester is a synthetic, lipid-soluble prodrug of lipoxin A4 (LXA4), a trihydroxy fatty acid and specialized pro-resolving lipid mediator derived from arachidonic acid via the action of lipoxygenase enzymes in human leukocytes[2][7]. The compound acts as an agonist at the Formyl peptide receptor 2 (ALX/FPR2) and mimics endogenous LXA4 activity. It promotes resolution of inflammation by inhibiting leukocyte activation, chemotaxis, natural killer cell function, and monocyte migration and adhesion[7][6]. Preclinical studies have shown efficacy in models of asthma and diabetic complications such as kidney disease and atherosclerosis[3][5]. The drug is primarily used as a research tool to study inflammation resolution pathways.
- Other names
- lipoxin A4 methyl esterLXA4 methyl esterLXA-4 methyl esterLXA 4 methyl ester97643-35-1
02
Targets
FPR2 (Formyl peptide receptor type 2)
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