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5,10,15,20-Tetrakis(4-sulfonatophenyl)-21H,23H-porphine
- Development stage
- Preclinical
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous, Intraarticular, Intralesional
01
Overview
**5,10,15,20-Tetrakis(4-sulfonatophenyl)-21H,23H-porphine (TSPP)** is a synthetic water-soluble porphyrin derivative. It is primarily used as a photosensitizer in photodynamic therapy (PDT), particularly for tumor treatment and theranostics of rheumatoid arthritis. The mechanism of action involves the absorption of light by the porphyrin core to generate reactive oxygen species that can induce cell death in targeted tissues. TSPP is also utilized in bio-imaging applications due to its photophysical properties[2][7].
- Other names
- 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrinTSPP
02
Targets
BCL-2 (BCL-2 family)
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