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5,7,2′-trihydroxy-6,8-dimethoxyflavone
- Development stage
- Preclinical
- Lead developer
- K36 Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
5,7,2′-trihydroxy-6,8-dimethoxyflavone (K36) is a naturally occurring flavonoid derivative isolated from the medicinal herb Scutellaria baicalensis. It is classified as a small molecule and has been studied for its high-affinity binding to the benzodiazepine site (BZD-S) of GABA-A receptors. This compound has been investigated for potential use in preventing or treating syndromes associated with benzodiazepine sites. Its mechanism involves modulation of central nervous system activity via interaction with GABA-A receptor subtypes[2][5]. The compound is considered experimental and not approved for clinical use.
- Other names
- 5,7-dihydroxy-2-(2-hydroxyphenyl)-6,8-dimethoxychromen-4-one5,7-Dihydroxy-2-(2-hydroxyphenyl)-6,8-dimethoxy-4H-chromen-4-on
02
Targets
GABRR (GABA-A receptor subunit rho)
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