5,7-dibromoisatin

5,7-dibromoisatin is a synthetic small molecule and brominated derivative of isatin. It exhibits potent cytotoxic activity against various human cancer cell lines, including colon, breast, lung, and melanoma cancers. The compound acts primarily as a microtubule-destabilizing agent by binding to tubulin and inhibiting its polymerization, leading to cell cycle arrest and apoptosis. It also serves as a key chemical scaffold for the synthesis of novel N-alkylated derivatives and other analogs with enhanced anticancer, anticonvulsant, or selective aldehyde dehydrogenase (ALDH) inhibitory activities. Preclinical research on 5,7-dibromoisatin and its derivatives has been primarily conducted by institutions such as the Penn State College of Medicine.

Other names

5,7-dibromo-1H-indole-2,3-dione5,7-dibromo-2,3-dihydro-1H-indole-2,3-dione5,7-dibromoindoline-2,3-dione