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5-aminoimidazole ribonucleoside

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
01

Overview

5-Aminoimidazole ribonucleoside is a synthetic or naturally occurring nucleoside in which a beta-D-ribofuranose sugar is N-linked to the imidazole ring at position 1, with an amino group at position 5 of the imidazole. It belongs to the class of imidazole ribonucleosides and is structurally related to intermediates in purine biosynthesis. The compound can be used experimentally as an exogenous source for cellular purine and thiamine requirements, as it can enter metabolic pathways leading to nucleotide and vitamin synthesis[1][2]. Its primary use has been in research settings rather than clinical medicine.

Other names
CHEBI:142416
02

Targets

ThiD (Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase)Nucleotide synth (Nucleotide synthesis enzymes)

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