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5-aminolevulinic acid + sodium fluorescein
- Development stage
- Unknown
- Lead developer
- NX Development Corp.
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A dual-labeling technique combining two fluorophores used primarily in neurosurgery for tumor visualization. 5-aminolevulinic acid (5-ALA) is metabolized within tumor cells to protoporphyrin IX (PPIX), which fluoresces red under blue light (400nm), while sodium fluorescein extravasates in areas of blood-brain barrier disruption, emitting yellow-green fluorescence under 560nm light. This combination provides complementary information on tumor cells and blood-brain barrier integrity, allowing better discrimination between necrosis, proliferating tumor, infiltrating tumor, and peritumoral edema during surgical procedures.
- Brand names
- Ak-fluorAltafluorDiofluorFluoresciteFluress
- Other names
- sodium fluorescein5-aminolevulinic acid
02
Targets
ALAD (5-aminolevulinic acid dehydratase)
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