Drug intelligence / Profile preview

5-Aminovaleric acid

Development stage
Unknown
Modality
Small Molecules
01

Overview

5-Aminovaleric acid, also known as Delta-Amino Valeric Acid, is a delta-amino acid and an omega-amino fatty acid. It is a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist. This compound is a human and microbial metabolite, found in the gut and in human saliva, with elevated concentrations observed in patients with chronic periodontitis. Additionally, it is recognized as an antifibrinolytic amino acid analog, acting as a weak inhibitor of the blood clotting pathway. It has been listed in pharmaceutical databases like DrugBank and ZINC15.

Other names
Delta-Amino Valeric Acid5-Aminopentanoic aciddelta-Aminovaleric aciddelta-Amino-n-valeric acidDAVADB02068DB-02068DB 020684-carboxybutylazanium4-carboxybutan-1-aminiumH-5-Ava-OHH5-Ava-OHH 5-Ava-OHHomopiperidinic acid5-amino-pentanoic acidValeric acid, 5-amino-5-aminopentanoate5-aminovalerate5-AMINO-N-VALERIC ACIDNSC-58383NSC58383NSC 58383NSC-73123NSC73123NSC 73123CHEBI:15887delta-aminovalerateBUW4BFJ6SCBUW-4BFJ6SCBUW 4BFJ6SCDTXSID70216212DTXSID-70216212DTXSID 70216212CHEBI:86394RefChem:532474DTXCID70138703DTXCID-70138703DTXCID 70138703211-544-55-azaniumylpentanoateDelta-Aminovalerianic AcidCHEMBL284116CHEMBL-284116CHEMBL 284116delta-Amino-n-valerateValeric acid, 5-amino- (8CI)
02

Targets

SLC6A6 (Solute carrier family 6 member 6)GABRR (GABA-A receptor subunit rho)GABA-B (Gamma-aminobutyric acid receptor type B)KDM6B (Lysine-specific demethylase 6B)

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