5-bromoindirubin

5-Bromoindirubin is a synthetic small molecule belonging to the indirubin family of compounds. It is structurally characterized as a brominated derivative of indirubin and has the chemical formula C16H9BrN2O2. The compound acts primarily as an inhibitor of cyclin-dependent kinase 2 (CDK2), with an IC50 value of approximately 80 nM[1]. This mechanism suggests potential utility in modulating cell cycle progression and proliferation. Preclinical research indicates that derivatives of 5-bromoindirubin exhibit anticancer activity by inhibiting cell cycle-related kinases such as CDKs and glycogen synthase kinase‑3β[3][5]. While it has been explored for its anticancer properties and structure–activity relationships in experimental settings, there are currently no approved indications or advanced clinical trials for this compound.

Other names

(2Z)-5'-bromo-2,3'-biindole-2',3(1H,1'H)-dione ammoniate(3Z)-5-Bromo-3-(3-oxo-1,3-dihydro-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one60874-72-8