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5-bromothienyldeoxyuridine
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
01
Overview
5-Bromothienyldeoxyuridine is a synthetic nucleoside analog of deoxyuridine in which the uracil base is substituted at the 5-position with a brominated thienyl group. It acts as an inhibitor of DNA synthesis by incorporating into DNA during replication, thereby disrupting normal DNA function. This compound has demonstrated potent and selective antiviral activity against herpes simplex virus type 1 (HSV‑1) and varicella-zoster virus (VZV) in preclinical studies. Its mechanism involves competition with natural nucleotides for incorporation into viral DNA, leading to inhibition of viral replication[4][5][7]. The drug is considered experimental and has not been approved for clinical use.
- Other names
- 5-(5-bromothien-2-yl)-2'-deoxyuridine5-(5-bromo-2-thienyl)-2'-deoxyuridineUridine, 5-(5-bromo-2-thienyl)-2'-deoxy-134333-70-3
02
Targets
Host nuclear DNA polymeraseHSV DNA pol (Herpes simplex virus DNA polymerase)
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