5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide

5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide is an experimental small molecule inhibitor of coagulation Factor Xa. It belongs to the benzamide class of compounds and was developed as part of a series aimed at identifying potent and selective inhibitors structurally distinct from pyrazole-based analogs. The compound has demonstrated anticoagulant activity in preclinical studies, with binding confirmed by X-ray crystallography in complex with Factor Xa. Its primary mechanism is inhibition of the serine protease activity of Factor Xa, a key enzyme in the blood coagulation cascade[1][3].

Other names

5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamideDB08173DB-08173DB 08173