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5-cyano-n-(2,5-dimethoxybenzyl)-6-ethoxypyridine-2-carboxamide
- Development stage
- Preclinical
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A synthetic small molecule inhibitor of c-Jun N-terminal kinases (JNKs), specifically designed as a potent and highly selective JNK inhibitor. JNKs are serine/threonine-protein kinases involved in cell signaling pathways that regulate processes such as cell proliferation, differentiation, apoptosis, and stress responses. Inhibition of JNK1 is particularly relevant for metabolic diseases like obesity and insulin resistance; JNK2 and JNK3 are implicated in inflammatory and neurological disorders. This compound was developed to explore the therapeutic potential of targeting these enzymes[1][4][5].
- Other names
- 5-cyano-n-(2,5-dimethoxybenzyl)-6-ethoxypyridine-2-carboxamide5-cyano-n-[(2,5-dimethoxyphenyl)methyl]-6-ethoxypyridine-2-carboxamide
02
Targets
JNK (Mitogen-activated protein kinase kinase kinase family)
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