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5-fluorouracil + doxorubicin + cyclophosphamide + toremifene

Development stage: Unknown
Lead developer: Farmitalia
Modality: Small Molecules
Administration: Oral, Intravenous

Overview

A chemoendocrine therapy regimen combining three chemotherapy agents (5-fluorouracil, doxorubicin, cyclophosphamide) with high-dose toremifene. This combination targets breast cancer cells through multiple mechanisms: 5-fluorouracil inhibits DNA synthesis, doxorubicin interferes with DNA replication and repair, cyclophosphamide damages DNA in cancer cells, and toremifene blocks estrogen receptors. The regimen is primarily used for advanced and recurrent breast cancer.

Other names: CAF + toremifeneCAFT

Targets

TOP2A (DNA topoisomerase II)ESR1 (ERα)DNATS (Thymidylate synthase)

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