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5-fluorouracil + selenium
- Development stage
- Preclinical
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
5-fluorouracil + selenium is an experimental combination therapy primarily researched for the treatment of colorectal cancer. 5-fluorouracil (5-FU) is a fluorinated pyrimidine that acts as an antimetabolite, inhibiting the enzyme thymidylate synthase and interfering with DNA and RNA synthesis. Selenium is a trace element that serves as a synergistic agent; it is thought to enhance the cytotoxic effects of 5-FU by inducing reactive oxygen species (ROS)-mediated apoptosis in cancer cells while simultaneously providing a protective effect against chemotherapy-induced side effects like diarrhea and weight loss. Recent studies have utilized advanced delivery systems, such as folate-conjugated thiolated chitosan nanoparticles, to provide pH-responsive, targeted delivery to the colon, thereby increasing efficacy and reducing systemic toxicity.
- Other names
- 5-FU + SeFluorouracil and Selenium
02
Targets
Cancer cell membraneDNATS (Thymidylate synthase)
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