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5-fluorouracil + Shi Quan Da Bu Tang + cyclophosphamide + docetaxel + doxorubicin + epirubicin

Development stage: Unknown
Lead developer: Sanofi
Modality: Small Molecules
Administration: Intravenous, Oral

Overview

This is a combination therapy consisting of multiple chemotherapeutic agents (5-fluorouracil, cyclophosphamide, docetaxel, doxorubicin, and epirubicin) along with Shi Quan Da Bu Tang, a traditional Chinese medicine formula. The chemotherapeutic components have different mechanisms of action: - 5-fluorouracil: An antimetabolite that stops cells from making and fixing DNA, causing cell death during division - Cyclophosphamide: An alkylating agent that stops cancer cells from reproducing - Docetaxel: A taxane that disrupts microtubule function essential for cell division - Doxorubicin: An anthracycline that stops DNA production and interferes with DNA repair enzymes - Epirubicin: An anthracycline similar to doxorubicin with slightly different toxicity profile - Shi Quan Da Bu Tang: A traditional Chinese medicine formula

Targets

TS (Thymidylate synthase)TOP2A (DNA topoisomerase II)DNATUBB (Tubulin (alpha and beta subunits))

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