5-fluorouridine

**5-fluorouridine** is a synthetic pyrimidine nucleoside analog in which the uracil base of uridine is substituted with a fluorine atom at the C‑5 position. It acts primarily as an antimetabolite and mutagen. In biological systems, it can be incorporated into RNA in place of uridine and disrupts normal RNA function and processing. Its main molecular target is uridine phosphorylase. While not approved for clinical use as an anticancer agent itself, it is structurally related to the widely used chemotherapeutic drug fluorouracil (5-FU), and often serves as a research tool for studying nucleic acid metabolism or comparing activity with other fluorinated pyrimidines[1][2][6].

Other names

5-Fluorouracil 1-beta-D-ribofuranoside5-fluorouracil-1beta-d-ribofuranoside5-Fluoro Uridine1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-fluoropyrimidine-2,4-dione