Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
5-methyl-N-(nitro-1,3-thiazol-2-yl)-3-phenylisoxazole-4-carboxamide
- Development stage
- Preclinical
- Lead developer
- Emory University
- Modality
- Small Molecules
01
Overview
5-methyl-N-(nitro-1,3-thiazol-2-yl)-3-phenylisoxazole-4-carboxamide is a small molecule dual inhibitor of **NADPH quinone oxidoreductase 1 (NQO1)** and **glutathione S-transferase pi 1 (GSTP1)**. Identified through high-throughput screening, this compound binds to both enzymes with high affinity and selectivity. By inhibiting NQO1 and GSTP1, it disrupts the redox homeostasis of cancer cells, leading to increased reactive oxygen species (ROS) and the activation of caspase-mediated apoptosis. It has demonstrated efficacy in mitigating the proliferation of **glioblastoma (GBM)** cells both in vitro and in vivo, suggesting potential as a novel therapeutic strategy for aggressive brain tumors.
- Other names
- 5-methyl-3-phenyl-N-(5-nitrothiazol-2-yl)isoxazole-4-carboxamide
02
Targets
NQO1GSTP1 (Glutathione S-transferase P)
Beyond the preview
Go deeper on 5-methyl-N-(nitro-1,3-thiazol-2-yl)-3-phenylisoxazole-4-carboxamide.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 5-methyl-N-(nitro-1,3-thiazol-2-yl)-3-phenylisoxazole-4-carboxamide.