5-methyltetrahydrofolate glucosamine salt

**5-methyltetrahydrofolate glucosamine salt** is a stable, bioactive form of folate (vitamin B9), where 5-methyltetrahydrofolic acid—the main circulating form of folate in the body—is present as its glucosamine salt for enhanced stability and bioavailability[2][4][6]. Unlike synthetic folic acid, which must be converted in the body, this form is biologically active and can be used directly, including by those with common MTHFR polymorphisms[2][6]. It is primarily used for treating folate deficiency and related indications such as anemia, prevention of neural tube defects, infertility, hyperhomocysteinemia, cardiovascular disease, mild cognitive impairment, and as part of prenatal nutrition and supplementation[1][2][6]. It is most widely known under the brand name Quatrefolic and is present in nutritional supplements and some pharmaceutical formulations[6]. Its mechanism involves direct participation in one-carbon metabolism, including DNA synthesis, methylation, and homocysteine remethylation[3][6].

Brand names

Quatrefolic

Other names

5-methyltetrahydrofolate glucosamineMethyltetrahydrofolic Acid Glucosamine Salt(6S)-5-methyltetrahydrofolic acid glucosamine saltL-5-methyltetrahydrofolate glucosamineL5-methyltetrahydrofolate glucosamineL 5-methyltetrahydrofolate glucosamine5-MTHF glucosamine