5-nitroindazole

**5-Nitroindazole** is a synthetic small molecule belonging to the indazole class of organic compounds. It is primarily used as a research chemical and pharmaceutical intermediate. Its main mechanism of action is the inhibition of nitric oxide synthase (NOS), particularly the inducible form (iNOS), and it also affects endothelial NOS. By inhibiting NOS, it reduces nitric oxide production, which plays a role in various physiological and pathological processes including inflammation and neurodegeneration[1][5][7]. In preclinical studies, it has demonstrated neuroprotective effects and potential anti-inflammatory activity. It has also shown antiparasitic activity against Trypanosoma cruzi in vitro[3][5]. While not approved for clinical use or marketed as a drug, it serves as an important tool compound in neuroscience research for studying nitric oxide pathways and related neurological disorders such as chronic graft-versus-host disease (GVHD) and tumors[4][9].

Other names

5-Nitro-1H-indazole1H-Indazole, 5-nitro-NSC 5032NSC5032NSC-5032CCRIS 4134CCRIS4134CCRIS-4134UNII 235Y7P37ZDUNII235Y7P37ZDUNII-235Y7P37ZDEINECS 226-451-5EINECS226-451-5EINECS-226-451-5BRN 0007936BRN0007936BRN-0007936DTXSID5049316DTXSID-5049316DTXSID 5049316Nitroindazole, 5