5A-POPC

**5A-POPC** is an experimental reconstituted high-density lipoprotein particle comprising the synthetic bihelical apolipoprotein A-I mimetic peptide 5A complexed with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine. It was investigated as an intravenous HDL-mimetic approach for atherosclerosis. The complex promotes cellular cholesterol efflux, particularly through ATP-binding cassette transporter A1, and can also support ATP-binding cassette transporter G1 and scavenger receptor class B member 1-mediated efflux. In animal studies, it increased reverse cholesterol transport, mobilized plasma cholesterol, displayed anti-inflammatory activity, and reduced aortic plaque burden in apolipoprotein E-deficient mice. It remains an experimental preclinical formulation rather than a marketed medicine. ([europepmc.org](https://europepmc.org/articles/PMC2913774))

Other names

5A + POPC5A-POPC5A/POPC5A-palmitoyl oleoyl phosphatidylcholine