5D11D4

5D11D4 is a **mouse IgG1 monoclonal antibody** directed against **placental growth factor** and used as a **preclinical biologic research therapeutic**. It inhibits the **PlGF and neuropilin 1 signaling axis**, a pathway implicated in angiogenesis, tumor growth, inflammatory cell recruitment, and fibrotic wound healing. In the literature provided, 5D11D4 was supplied by **ThromboGenics** and investigated in animal models of **medulloblastoma**, **glaucoma filtration surgery failure**, and **wound healing/scarring**, where it showed antitumor, anti-angiogenic, and anti-fibrotic effects. The available evidence supports that this agent remained an experimental research antibody rather than a clinically developed marketed drug.

Other names

anti-mouse placental growth factor monoclonal antibody