5F-MDMB-PICA

5F-MDMB-PICA is a synthetic cannabinoid belonging to the indole-based class of designer drugs. Its IUPAC name is methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indole‑3-carbonyl]amino}-⁠⁠⁠⁠⁠⁠⁠⁠‍‍‍‍‍‍‍‌​‌‌‌​‌‌‌​​‌‌​​​​​​​​​​​​​​‌​‌‌​​​‎‎‏‏‏‎‎‏‏‎⁦‪⁩⁦‪⁩⁦‪⁩³,³-dimethylbutanoate. It acts as a potent full agonist at both the cannabinoid CB₁ and CB₂ receptors with EC₅₀ values of approximately 0.45 nM and 7.4 nM respectively—significantly more potent than Δ9-tetrahydrocannabinol (THC)[2][4]. The compound produces psychoactive effects similar to THC but has been associated with severe adverse events including fatalities in humans[4][10]. It is classified as a Schedule I controlled substance in the United States and Schedule II under the Convention on Psychotropic Substances of 1971 due to its high abuse potential and lack of accepted medical use[7][10]. The drug is typically encountered as a component in herbal smoking mixtures or e-liquids for vaping.

Other names

5-Fluoro-MDMB-PICAMethyl (2S)-2-[1-(5-fluoropentyl)-1H-indole-3-carboxamido]-3,3-dimethylbutanoatemethyl (2s)-2-{[1-(5-fluoropentyl)-1h-indole-3-carbonyl]amino}-3,3-dimethylbutanoateMethyl N-{[1-(5-fluoropentyl)-1H-indol-3-yl]carbonyl}-3-methyl-L-valinateL-Valine, N-[[1-(5-fluoropentyl)-1H-indol-3-yl]carbonyl]-3-methyl-, methyl esterN-[[1-(5-Fluoropentyl)]-1H-indol-3-yl]carbonyl]-3-methyl-L-valine methyl ester5F-MDMB-PICA; Methyl (2S)-2-(1-(5-fluoropentyl)-1H-indole‑3‑carboxamido)‑3,3‑dimethylbutanoate5F-MDMB‑2201