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5R-hydroxy-6E,8Z,11Z,14Z,17Z-eicosapentaenoic acid

Development stage: Preclinical
Modality: Small Molecules

Overview

This compound is a hydroxy derivative of eicosapentaenoic acid (EPA), specifically hydroxylated at the 5-position with defined stereochemistry. It is an experimental small molecule lipid mediator and a member of the specialized pro-resolving mediators (SPMs) family derived from omega-3 fatty acids. It has been studied for its potential biological activity as an agonist of peroxisome proliferator-activated receptors (PPARs), particularly PPARγ and possibly PPARδ. These nuclear receptors are involved in regulating inflammation and metabolic processes. The compound is not approved for clinical use but has been investigated in research settings for its anti-inflammatory properties[10][8].

Other names: (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)

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