6-chloromelatonin

6-chloromelatonin is a **synthetic melatonin receptor agonist** with notably greater metabolic stability and higher receptor affinity than endogenous melatonin. It acts as a potent agonist at both the **MT1** and **MT2** melatonin receptors, displaying pKi values of 9.1 and 9.77, respectively. Compared to melatonin, 6-chloromelatonin demonstrates stronger binding to melatonin receptors in mammalian and avian models. It has been used primarily in research applications related to circadian rhythm and sleep regulation. There is currently no marketed therapeutic use or indication; sale is restricted to laboratory research. There is no evidence it has been developed by, or is manufactured by, major pharmaceutical companies for clinical use[2][3][4][6].

Other names

N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamideCAS 63762-74-3CAS63762-74-3CAS-63762-74-3