Drug intelligence / Profile preview

6-gingerol

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

6-Gingerol is a naturally occurring plant phenol and the major pungent constituent found in the rhizome of ginger (*Zingiber officinale*). It is known for its anti-inflammatory, antioxidant, and anticancer properties. The compound acts as a beta-hydroxy ketone and has been shown to inhibit adipogenesis. Its pharmacological activities include effects on apoptosis induction, cell cycle regulation, cytotoxic activity against cancer cells, inhibition of angiogenesis, and modulation of transient receptor potential (TRP) channels. 6-Gingerol is under investigation for various therapeutic applications due to its safety profile and multi-target effects[2][7][3].

Other names
GINGEROL(S)-[6]-Gingerol(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone
02

Targets

KCNK3 (Two-pore domain potassium channel subfamily K member 3 (TASK-3))TRPV1 (Transient receptor potential cation channel subfamily V member 1)KCNK18 (TWIK-related spinal cord potassium channel)

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