6-hydroxy-1,6-dihydro purine nucleoside

"6-hydroxy–1,6–dihydropurine nucleoside" is a synthetic purine nucleoside analog and a small molecule that acts as a potent inhibitor of adenosine deaminase (ADA), an enzyme critical in purine metabolism. It functions as a transition-state or reaction coordinate analogue for ADA and binds tightly to the enzyme's active site via multiple hydrogen bonds. This compound has been used experimentally to study ADA structure and function but is not approved for clinical use or marketed as a pharmaceutical product. Its primary utility is in biochemical research related to ADA inhibition[1][8][6].

Other names

6-Hydroxy-1,6-Dihydro Purine Nucleoside(6S)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-hydroxy-6,7-dihydro-3H-9lambda5-purin-9-ylium(6S)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-hydroxy-6,7-dihydro‑3H‑9lambda5‑purin‑9‑ylium(6S)-6-hydroxy‑9-beta-D-ribofuranosyl‑6,9-dihydro‑1H-purin–7–ium