6-mercaptopurine riboside

6-mercaptopurine riboside is a **small molecule purine analog** that is a riboside derivative of 6-mercaptopurine. Like its parent compound, it functions as an **inhibitor of de novo purine synthesis** and interconversion pathways. 6-mercaptopurine riboside acts primarily through inhibition of **phosphoribosyl amidotransferase (PPAT)**, which is key in the first step of purine nucleotide biosynthesis. It has been studied as an antineoplastic agent, particularly in the context of **neoplasms** and disorders related to **purine metabolism**. Its primary experimental indications relate to cancer, including pancreatic cancer and potentially other types of neoplasms[1][2].

Other names

6-MPR6-Methylmercaptopurine riboside6-(Methylthio)purine ribonucleoside6-S-methyl-6-thioinosine