6-methoxydihydrosanguinarine

6-methoxydihydrosanguinarine is a natural benzophenanthridine alkaloid derived from medicinal plants that exhibits significant antitumor activity. Its mechanism of action primarily involves the induction of reactive oxygen species (ROS) accumulation, which serves as a key driver for its cytotoxic effects. This ROS accumulation subsequently triggers the activation of the c-Jun N-terminal kinase (JNK) signaling pathway, induces endoplasmic reticulum (ER) stress, and promotes autophagy-mediated cell death. Preclinical studies in human non-small cell lung cancer (NSCLC) models have demonstrated that 6-methoxydihydrosanguinarine can synergistically enhance the efficacy of cisplatin, suggesting its potential as a combination therapy candidate for lung cancer.

Other names

6-methoxy-5,6-dihydrosanguinarine