6-methyl-formycin A

**6-methyl-formycin A** is a synthetic or naturally derived C-nucleoside analog structurally related to formycin A. It belongs to the class of c-glycosyl compounds and features a pyrazolopyrimidine ring system with a methyl group at the sixth position. While detailed pharmacological data for this specific analog are limited in public databases and literature as of June 2025[1][2][3], its parent compound (formycin A) is known for cytotoxicity and broad-spectrum biological activities including antiviral (notably anti-HIV), antibiotic (antibacterial), antitumor and antiparasitic effects[5][7]. The mechanism of action for formycins generally involves acting as nonhydrolyzable analogs of AMP after phosphorylation within cells; they inhibit enzymes such as AMP nucleosidase and purine nucleoside phosphorylase (PNP), disrupt purine metabolism/recycling in target organisms or cells[5]. There are no approved clinical indications or ongoing clinical trials for this compound.

Other names

6-METHYL-FORMYCIN A7-amino-3-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-methyl-2H-pyrazolo(4,3-d)pyrimidin-6-ium7-amino-3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl-2H-pyrazolo[4,3-d]pyrimidin-6-ium2-(7-amino‑6‑methyl‑3H‑pyrazolo[4,3‑d]pyrimidin‑3‑yl)–5-hydroxymethyl-tetrahydro-furan–3,4–diol