6-MOMIPP

6-MOMIPP (3-(6-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one) is a synthetic indole-based chalcone that acts as a potent microtubule-disrupting agent. Developed by researchers at the University of Toledo, it is a structural isomer of 5-MOMIPP. While 5-MOMIPP induces a non-apoptotic cell death called methuosis, 6-MOMIPP causes rapid disruption of microtubules by competing for the colchicine-binding site on tubulin. This leads to mitotic arrest and subsequent caspase-independent cell death. 6-MOMIPP has shown high potency against glioblastoma and melanoma cell lines in vitro and demonstrates the ability to cross the blood-brain barrier in murine models, suggesting potential utility in treating primary and metastatic brain tumors.

Other names

3-(6-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propene-1-one