6-O-cyclohexylmethyl guanine

**6-O-cyclohexylmethyl guanine** is a synthetic small molecule nucleoside analog and a modified derivative of guanine. It acts primarily as an inhibitor of cyclin-dependent kinase 2 (CDK2), with additional inhibitory activity against cyclin-A2. The compound has been investigated for its potential anticancer and antiviral properties, but it remains experimental and is not approved for clinical use. Its mechanism involves interfering with cell cycle regulation by inhibiting CDK2, which may result in antiproliferative effects on cancer cells[1][3][4]. No approved indications or marketed formulations are currently available.

Other names

6-(cyclohexylmethoxy)-9H-purin-2-amineO6-cyclohexylmethylguanineO-6-cyclohexylmethylguanineO 6-cyclohexylmethylguanineO6-(cyclohexylmethyl)guanineO-Cyclohexylmethylguanine2-amino-6-cyclohexylmethoxypurine2-amino-6-[cyclohexylmethyl)oxy]purine