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Drug intelligence / Profile preview
6-shogaol
- Development stage
- Preclinical
- Lead developer
- Shanghai University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
6-shogaol is a **natural phenolic compound** formed from 6-gingerol by dehydration, and is a major bioactive principle found in dried ginger (Zingiber officinale) rhizomes. It exhibits potent anti-inflammatory and antioxidant properties. Mechanistically, 6-shogaol inhibits inflammatory signaling by downregulating pro-inflammatory cytokines (e.g. TNF, IL-1β, IL-6, IL-8), reducing nuclear factor kappa B (NFκB) activation, suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, and modulating PI3K/Akt, MAPK, and Nrf2/ARE pathways. It is investigated mainly as a research compound and a potential dietary supplement ingredient. No drug development by pharmaceutical companies is reported; it is widely studied for its anti-inflammatory, antioxidant, neuroprotective, and anti-cancer effects[1][3].
- Other names
- SHOGAOL6-SHOGAOL6-ShagaolSHOGAOL 6-SHOGAOL6-SHOGAOL-6-6-gingerenol[6]-Shogaol6-Shogaol USP/EP/BP6-Shogaol-RMShogaol 10 mM in DMSOShogaol10 mM in DMSOShogaol-10 mM in DMSO
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MAPK3 (Mitogen-activated protein kinase 1)HSP60 (60 kDa heat shock protein, mitochondrial)NOS2 (Nitric Oxide Synthase 2)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)GSH (Glutathione)TXNRD2 (Thioredoxin reductase 2)MEKPPARG (Peroxisome proliferator-activated receptor gamma)
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