61Cu-NODAGA-PSMA

61Cu-NODAGA-PSMA is an investigational radiopharmaceutical diagnostic imaging agent designed for positron emission tomography (PET) imaging of prostate cancer. It consists of the positron-emitting radioisotope Copper-61 ($^{61}$Cu) complexed with the bifunctional chelator NODAGA (1,4,7-triazacyclononane-1-glutaric acid-4,7-diacetic acid), which is conjugated to a small molecule ligand targeting Prostate-Specific Membrane Antigen (PSMA). PSMA is a transmembrane protein highly overexpressed in prostate cancer cells, making it an ideal target for molecular imaging. The choice of Copper-61 is notable for its 3.3-hour half-life, which is longer than the common PET isotopes Fluorine-18 and Gallium-68, potentially allowing for centralized production and a wider geographic distribution range to clinics without on-site cyclotrons.

Other names

Cu-61-NODAGA-PSMACu61-NODAGA-PSMACu 61-NODAGA-PSMACopper-61-NODAGA-PSMACopper61-NODAGA-PSMACopper 61-NODAGA-PSMA