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64Cu-Comb
- Development stage
- Unknown
- Lead developer
- University of California, Santa Barbara
- Modality
- Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems, Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
64Cu-Comb is a polymeric nanoparticle radiolabeled with the positron-emitting isotope Copper-64 (64Cu). It is designed for use in Positron Emission Tomography (PET) imaging. In the provided context, it primarily serves as a non-targeted control or as a foundational component for the development of targeted imaging agents, such as 64Cu-CANF-Comb, which is conjugated with C-type atrial natriuretic factor (CANF) to specifically target natriuretic peptide clearance receptors (NPRC) in atherosclerotic plaque.
- Other names
- Comb
02
Targets
NPR3 (Natriuretic peptide receptor C)
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