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64Cu-DOTA-C-ANF is a radiopharmaceutical compound consisting of the atrial natriuretic factor (ANF) peptide conjugated to the chelator DOTA and labeled with the positron-emitting isotope copper-64 (64Cu). It is designed as a molecular imaging agent for positron emission tomography (PET) imaging and is used primarily in research applications to visualize and quantify atrial natriuretic peptide receptor (NPR-A/NPR-C) expression in vivo. The mechanism of action involves selective binding of the conjugated ANF peptide to natriuretic peptide receptors, allowing the visualization of receptor distribution and density via PET imaging. Its development is preclinical or early clinical, often intended for cardiovascular disease research and receptor imaging in related pathologies.
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