Drug intelligence / Profile preview

64Cu-DOTA-C-ANF

Development stage
Preclinical
Lead developer
Washington University School of Medicine
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Positron Emitters → Radiopharmaceuticals, Peptides
Administration
Intravenous
01

Overview

64Cu-DOTA-C-ANF is a radiopharmaceutical compound consisting of the atrial natriuretic factor (ANF) peptide conjugated to the chelator DOTA and labeled with the positron-emitting isotope copper-64 (64Cu). It is designed as a molecular imaging agent for positron emission tomography (PET) imaging and is used primarily in research applications to visualize and quantify atrial natriuretic peptide receptor (NPR-A/NPR-C) expression in vivo. The mechanism of action involves selective binding of the conjugated ANF peptide to natriuretic peptide receptors, allowing the visualization of receptor distribution and density via PET imaging. Its development is preclinical or early clinical, often intended for cardiovascular disease research and receptor imaging in related pathologies.

02

Targets

NPR3 (Natriuretic peptide receptor C)NPR (Natriuretic peptide receptor family)

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