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64Cu-EB-ss-CPT
- Development stage
- Unknown
- Lead developer
- Peking Union Medical College Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
64Cu-EB-ss-CPT is a radionuclide-labeled self-assembly nanomedicine developed for cancer theranostics. It consists of copper-64 (64Cu) labeled Evans blue conjugated camptothecin (EB-CPT) which forms nanoparticles through self-assembly due to its inherent amphiphilicity. The nanoparticles exhibit favorable blood circulation properties and prolonged tumor retention in tumor-bearing mice. The drug leverages the enhanced permeability and retention (EPR) effect to accumulate in tumor tissues, making it useful for PET/CT imaging of colorectal cancer. The EB component acts as an albumin binder to enhance tumor accumulation while maintaining safety and diagnostic efficacy.
- Other names
- 64Cu-NOTA-EB-CPT64Cu-NOTA-EB-ss-CPT
02
Targets
TOP1 (DNA Topoisomerase I)
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