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64Cu-NODAGA-PD-L1
- Development stage
- Preclinical
- Lead developer
- Helmholtz-Zentrum Dresden-Rossendorf
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
64Cu-NODAGA-PD-L1 is a copper-64 labeled small-molecule radiotracer developed by the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) for positron emission tomography (PET) imaging of programmed cell death ligand 1 (PD-L1) expression in tumors. The tracer consists of a biphenyl-based small-molecule PD-L1 inhibitor core modified with hydrophilic linker units, water-solubilizing sulfonate and/or phosphonate groups, and a NODAGA chelator for stable complexation of copper-64. By non-invasively visualizing the heterogeneous expression of PD-L1 across tumor sites, 64Cu-NODAGA-PD-L1 is designed to serve as a diagnostic tool to identify patients likely to respond to immune checkpoint inhibitor (ICI) therapies, thereby supporting clinical therapy decisions.
- Other names
- [64Cu]Cu-NODAGA-PD-L1
02
Targets
CD274 (Programmed cell death protein 1 ligand 1)
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