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64Cu-NOTA-heterodimer-ZW800

Development stage: Preclinical
Lead developer: Altor BioScience
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

**64Cu-NOTA-heterodimer-ZW800** is an investigational dual-modality, bispecific antibody-fragment imaging agent developed for preclinical imaging of pancreatic cancer. It is a heterodimer assembled from Fab′ fragments targeting **endoglin (CD105)** and **tissue factor (TF)**, conjugated to the copper-64 chelator NOTA for positron-emission tomography and to the near-infrared fluorescent dye ZW800 for fluorescence imaging. In CD105- and TF-positive BxPC-3 pancreatic cancer xenografts, the tracer showed higher tumor uptake than corresponding single-target homodimers, and tumor localization was reduced by blocking either target, supporting dual-target-specific accumulation.

Other names: 64Cu-NOTA-heterodimer–ZW800

Targets

ENG (Integrin Beta 6)F3 (Tissue factor)

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