64Cu-NOTA-JR11

64Cu-NOTA-JR11 is a radiopharmaceutical used for positron emission tomography (PET) imaging. It consists of the somatostatin receptor antagonist peptide JR11 conjugated to the chelator NOTA and labeled with the radioisotope copper-64. The drug specifically targets somatostatin receptor subtype 2 (SSTR2), which is overexpressed in many neuroendocrine tumors (NETs). As an antagonist, it binds to SSTR2 on tumor cells but does not internalize as efficiently as agonists; however, it demonstrates strong receptor-mediated uptake at the cell membrane and high tumor-to-background ratios due to rapid blood clearance and efficient kidney washout. This results in high sensitivity for detecting SSTR2-positive lesions in NET patients using PET imaging[3]. The use of copper-64 provides a longer half-life than gallium-68 tracers, allowing for delayed imaging and potentially improved lesion detection.

Other names

copper-64 NOTA-JR11copper64 NOTA-JR11copper 64 NOTA-JR11copper-64-labeled NOTA-JR11copper64-labeled NOTA-JR11copper 64-labeled NOTA-JR1164Cu-labeled NOTA-JR11