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64Cu-NOTA-TSHR-Fab
- Development stage
- Preclinical
- Lead developer
- Mayo Clinic
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Positron Emitters → Radiopharmaceuticals, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
64Cu-NOTA-TSHR-Fab is a preclinical radiopharmaceutical imaging agent designed for immuno-positron emission tomography (immuno-PET) imaging of thyroid-stimulating hormone receptor (TSHR) expression in thyroid cancer. It consists of the antigen-binding fragment (Fab) of the human anti-TSHR monoclonal antibody K1-70, conjugated to the bifunctional chelator 2-S-(4-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (p-SCN-Bn-NOTA) and radiolabeled with the positron emitter copper-64 (64Cu). By targeting TSHR, which is highly expressed in thyroid cancer, 64Cu-NOTA-TSHR-Fab enables noninvasive detection of TSHR expression to help guide TSHR-targeted therapies. In preclinical mouse models of thyroid cancer, the radiotracer demonstrated rapid and superior TSHR-specific tumor accumulation, fast clearance, and low background signal compared to its single-chain variable fragment (scFv) counterpart.
- Other names
- [64Cu]Cu-NOTA-TSHR-Fab64Cu-labeled anti-TSHR K1-70 antibody fragment antigen-binding64Cu-labeled TSHR-Fabcopper-64-labeled anti-TSHR K1-70 Fabcopper64-labeled anti-TSHR K1-70 Fabcopper 64-labeled anti-TSHR K1-70 Fab
02
Targets
TSHR (Thyroid-stimulating hormone receptor)
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