Drug intelligence / Profile preview

64Cu-RTX-4002

Development stage: Unknown
Lead developer: Ratio Therapeutics
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Positron Emitters → Radiopharmaceuticals, Small Molecules
Administration: Intravenous

Overview

64Cu-RTX-4002 is a copper-64 labeled, small-molecule positron emission tomography (PET) imaging radiotracer targeting Granzyme B. Originally developed by Merck & Co. and subsequently licensed to Ratio Therapeutics, the probe utilizes an N3O2 NOTA chelator to form a stable complex with copper-64, offering improved chemical stability and radiochemical purity over its predecessor, 64Cu-RTX-4001. Granzyme B is a serine protease released by activated cytotoxic T lymphocytes and natural killer cells, serving as a key biomarker for immune activation. 64Cu-RTX-4002 is being evaluated in early-phase clinical trials to assess its pharmacokinetics, biodistribution, and dosimetry in healthy volunteers, with potential applications in monitoring immune responses in oncology, autoimmune, and inflammatory diseases.

Other names: [64Cu]RTX-4002

Targets

GZMB (Granzyme B)

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