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64Cu-S1PR2-amide-DOTA
- Development stage
- Preclinical
- Lead developer
- University of North Carolina at Chapel Hill
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta-minus Emitters → Radiopharmaceuticals, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
64Cu-S1PR2-amide-DOTA is a copper-64 labeled small molecule positron emission tomography (PET) radiotracer targeting sphingosine-1-phosphate receptor 2 (S1PR2). Developed by the University of North Carolina at Chapel Hill and Washington University School of Medicine, the agent consists of an S1PR2-targeting amide ligand conjugated to the chelator DOTA and radiolabeled with copper-64. S1PR2 is a G protein-coupled receptor implicated in cancer pathogenesis, demyelinating diseases, inflammation, and anaphylaxis. 64Cu-S1PR2-amide-DOTA is designed for noninvasive PET imaging to assess S1PR2 expression and distribution in tumors, such as melanoma and glioblastoma, to aid in disease characterization and therapeutic evaluation.
- Other names
- 64Cu-S1PR2-amide-DOTA64Cu-labeled S1PR2-amide-DOTA
02
Targets
S1PR2 (S1P receptor 2)
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