64Cu-SAR-bombesin

**64Cu-SAR-bombesin** is a radiopharmaceutical diagnostic and theranostic agent developed for the detection and potential treatment of cancers that express the gastrin-releasing peptide receptor (GRPR). It consists of bombesin, a peptide that binds with high affinity to GRPR, conjugated to a chelator (SAR) and labeled with the radioisotope copper-64. The drug is primarily used as a positron emission tomography (PET) imaging agent, enhancing visualization of GRPR-expressing tumors. These tumors include prostate cancer, breast cancer (especially ER-positive subtypes), ovarian cancer, urinary cancers, small cell lung cancer, glioblastoma, and gastrointestinal stromal tumors. The mechanism involves specific binding to GRPR on tumor cells followed by PET imaging or targeted radiotherapy when paired with therapeutic isotopes such as copper-67[1][2][3][4][5][6].

Other names

copper Cu 64 SAR-bombesin