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68Ga-A9-0922

Development stage: Preclinical
Lead developer: Alpha-9 Oncology
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration: Intravenous

Overview

68Ga-A9-0922 is a diagnostic radiopharmaceutical developed by Alpha-9 Oncology for the imaging of solid tumors, specifically pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer. It consists of a ligand (A9-0922) targeting **integrin alpha-v beta-6 (αvβ6)**, which is chelated with the positron-emitting radioisotope **Gallium-68 (68Ga)** for use in Positron Emission Tomography (PET). Integrin αvβ6 is a cell surface receptor that is significantly upregulated in various epithelial cancers and is associated with tumor progression and poor prognosis, while remaining largely absent in healthy adult tissues. The agent is currently in IND-enabling studies as part of a theranostic pair, intended to identify patients suitable for targeted radioligand therapy.

Other names: [68Ga]Ga-A9-0922

Targets

αVβ6 (Integrin αVβ6)

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