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68Ga-ACLY-DE
- Development stage
- Unknown
- Lead developer
- Air Force Military Medical University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
68Ga-ACLY-DE is a gallium-68-labeled molecular imaging probe designed to target ATP-citrate lyase (ACLY), a key rate-limiting enzyme in the fatty acid synthesis pathway. Developed by Xijing Hospital of the Fourth Military Medical University, the radiopharmaceutical is utilized in positron emission tomography (PET) imaging to non-invasively monitor the evolution of fatty acid synthesis-mediated drug resistance in patients with BRAF-mutant melanoma undergoing targeted therapies (such as vemurafenib). By binding specifically to ACLY, 68Ga-ACLY-DE allows for the quantitative and qualitative assessment of enzyme activity, aiding in the detection, staging, and recurrence monitoring of melanoma lesions.
- Other names
- 68Ga-ACLY-DE PET/CTgallium Ga 68 ACLY-DEgallium-68 ACLY-DEgallium68 ACLY-DEgallium 68 ACLY-DE
02
Targets
ACLY (ATP-citrate synthase)
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