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68Ga-BBN-IRDye800CW
- Development stage
- Phase 1
- Lead developer
- Deling Li
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
68Ga-BBN-IRDye800CW is an experimental dual-modality imaging probe designed for preoperative positron emission tomography (PET) and intraoperative near-infrared fluorescence (NIRF) imaging. The probe consists of a bombesin (BBN) peptide analogue, which specifically targets the gastrin-releasing peptide receptor (GRPR), conjugated to both the radioisotope gallium-68 (via a NOTA chelator) and the fluorescent dye IRDye800CW. GRPR is frequently overexpressed in various tumors, including lower-grade gliomas. This dual-modality approach allows for high-sensitivity metabolic imaging via PET to locate the tumor preoperatively, followed by real-time fluorescence navigation to assist surgeons in identifying tumor margins and achieving more precise resection during the operation.
- Other names
- IRDye800CW-BBN PET-NIRFIRDye-800CW-BBN PET-NIRFIRDye 800CW-BBN PET-NIRF68Ga-BBN-IRDye800CW dual-modality probe
02
Targets
GRPR (Gastrin-releasing peptide receptor)BRS3 (Bombesin receptor subtype 3)NMBR (Neuromedin B receptor)
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