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68Ga-CAIX
- Development stage
- Phase 1
- Lead developer
- Peking University First Hospital
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals
- Administration
- Intravenous
01
Overview
68Ga-CAIX is a gallium-68 (68Ga) labeled radiopharmaceutical targeting carbonic anhydrase IX (CAIX), designed as a positron emission tomography (PET) imaging tracer. CAIX is a transmembrane glycoprotein that is highly overexpressed in clear cell renal cell carcinoma (ccRCC) and various other hypoxic solid tumors, while its expression in normal tissues is highly restricted. By binding specifically to CAIX, 68Ga-CAIX allows for high-contrast, non-invasive visualization of CAIX-expressing primary and metastatic lesions. It is being clinically evaluated, notably by Peking University First Hospital, for the detection, characterization, and staging of renal tumors and other solid malignancies.
- Other names
- [68Ga]Ga-CAIX68Ga-CAIX PET/CT68Ga-labeled CAIX ligand68Ga-labeled CAIX tracer68Ga-labeled CAIX-targeted PET/CT
02
Targets
CA1 (Carbonic anhydrase 1)CA2 (Carbonic Anhydrase 2)CA9 (Carbonic anhydrase IX)CA12 (Carbonic anhydrase XII)
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