Drug intelligence / Profile preview

68Ga-CAIX-targeted polypeptide molecular probe

Development stage
Unknown
Lead developer
Harbin Medical University Cancer Hospital
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
Administration
Intravenous
01

Overview

68Ga-CAIX-targeted polypeptide molecular probe is a diagnostic radiopharmaceutical developed by Harbin Medical University Cancer Hospital for the detection of early metastasis in urinary tract tumors, including kidney cancer. The probe consists of a polypeptide ligand that specifically targets Carbonic Anhydrase IX (CAIX), a transmembrane protein that is constitutively overexpressed in clear cell renal cell carcinoma (ccRCC) and other hypoxic tumors. By labeling this polypeptide with the positron-emitting isotope Gallium-68 (68Ga), the probe enables high-sensitivity PET-CT imaging to visualize CAIX-positive lesions and assess biodistribution and radiation dosimetry in patients.

Other names
68Ga-CAIX-targeted polypeptideCAIX-targeted 68Ga polypeptide molecular probeCAIX-targeted68Ga polypeptide molecular probeCAIX-targeted-68Ga polypeptide molecular probe68Ga-labeled CAIX-targeted polypeptide
02

Targets

CA9 (Carbonic anhydrase IX)

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